The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis

被引：507

作者：

Booth, Heather D. E. ^{[1
,2
]}

Hirst, Warren D. ^{[3
]}

Wade-Martins, Richard ^{[1
,2
]}

机构：

[1] Univ Oxford, Oxford Parkinsons Dis Ctr, Oxford, England

[2] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

[3] Biogen, Cambridge, MA USA

来源：

TRENDS IN NEUROSCIENCES | 2017年 / 40卷 / 06期

基金：

英国医学研究理事会;

关键词：

RECESSIVE JUVENILE PARKINSONISM; DJ-1; KNOCK-DOWN; ALPHA-SYNUCLEIN; NEUROTROPHIC FACTOR; INFLAMMATORY RESPONSES; LIPID RAFTS; DOPAMINERGIC-NEURONS; ARACHIDONIC-ACID; GAUCHER-DISEASE; MITOCHONDRIAL DYSFUNCTION;

D O I：

10.1016/j.tins.2017.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson's disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment.

引用

页码：358 / 370

页数：13

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