Induction of tolerance and mossy fibre neuropeptide-Y expression in the contralateral hippocampus following a unilateral intrahippocampal kainic acid injection in the rat

被引：16

作者：

ElBahh, B

Lurton, D

Sundstrom, LE

Rougier, A

机构：

[1] UNIV BORDEAUX 2,LAB NEUROBIOL & NEUROIMAGERIE EXPT,F-33076 BORDEAUX,FRANCE

[2] SOUTHAMPTON GEN HOSP,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1997年 / 227卷 / 02期

关键词：

kainic acid; epilepsy; neuropeptide-Y; hippocampus; neuroprotection;

D O I：

10.1016/S0304-3940(97)00261-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously reported an ectopic expression of neuropeptide-Y (NPY) immunoreactivity in messy fibres (MFs) in the contralateral hippocampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection, resulting in a reduction in the number of overt seizures and degree of cell loss. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：135 / 139

页数：5

共 31 条

[1] Pre-exposure to subtoxic levels prevents kainic acid lesions in organotypic hippocampal slice cultures: Effects of kainic acid on parvalbumin-immunoreactive neurons and expression of heat shock protein 72 following the induction of tolerance
Best, N
Sundstrom, LE
Mitchell, J
Wheal, HV
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (06) : 1209 - 1219
[2] INVESTIGATIONS INTO NEUROPEPTIDE Y-MEDIATED PRESYNAPTIC INHIBITION IN CULTURED HIPPOCAMPAL-NEURONS OF THE RAT
BLEAKMAN, D
HARRISON, NL
COLMERS, WF
MILLER, RJ
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (02) : 334 - 340
[3] EFFECTS OF BILATERAL CLAMPING OF CAROTID ARTERIES ON HIPPOCAMPAL KINDLING IN RATS
BORTOLOTTO, ZA
HEIM, C
SIEKLUCKA, M
BLOCK, F
SONTAG, KH
CAVALHEIRO, EA
[J]. PHYSIOLOGY & BEHAVIOR, 1991, 49 (04) : 667 - 671
[4] ABERRANT EXPRESSION OF NEUROPEPTIDE-Y IN HIPPOCAMPAL MOSSY FIBERS IN THE ABSENCE OF LOCAL CELL INJURY FOLLOWING THE ONSET OF SPIKE-WAVE SYNCHRONIZATION
CHAFETZ, RS
NAHM, WK
NOEBELS, JL
[J]. MOLECULAR BRAIN RESEARCH, 1995, 31 (1-2): : 111 - 121
[5] NT-3 AND BDNF PROTECT CNS NEURONS AGAINST METABOLIC EXCITOTOXIC INSULTS
CHENG, B
MATTSON, MP
[J]. BRAIN RESEARCH, 1994, 640 (1-2) : 56 - 67
[6] PRESYNAPTIC INHIBITION BY NEUROPEPTIDE-Y IN RAT HIPPOCAMPAL SLICE INVITRO IS MEDIATED BY A Y2 RECEPTOR
COLMERS, WF
KLAPSTEIN, GJ
FOURNIER, A
STPIERRE, S
TREHERNE, KA
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 102 (01) : 41 - 44
[7] REGULATION OF NEUROPEPTIDES IN ADULT-RAT FOREBRAIN BY THE NEUROTROPHINS BDNF AND NGF
CROLL, SD
WIEGAND, SJ
ANDERSON, KD
LINDSAY, RM
NAWA, H
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (08) : 1343 - 1353
[8] REGIONALLY SPECIFIC AND RAPID INCREASES IN BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN THE ADULT-RAT BRAIN FOLLOWING SEIZURES INDUCED BY SYSTEMIC ADMINISTRATION OF KAINIC ACID
DUGICHDJORDJEVIC, MM
TOCCO, G
LAPCHAK, PA
PASINETTI, GM
NAJM, I
BAUDRY, M
HEFTI, F
[J]. NEUROSCIENCE, 1992, 47 (02) : 303 - 315
[9] ERIKSON J, 1996, NATURE, V381, P415
[10] Freund TF, 1996, HIPPOCAMPUS, V6, P347, DOI 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO

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