Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis

被引：53

作者：

Lin, Yun-Sheng ^{[1
,2
]}

Chen, Chung-Hsiung ^{[1
]}

Liaw, Chia-Ching ^{[1
,2
]}

Chen, Yu-Chen ^{[1
]}

Kuo, Yao-Haur ^{[3
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

TETRAHEDRON | 2009年 / 65卷 / 45期

关键词：

MARINE-INVERTEBRATES; COELENTERATA; OCTOCORALLIA; COLLECTION; GIBBEROSA; CHEMISTRY; DISSECTA;

D O I：

10.1016/j.tet.2009.09.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigation of the soft coral Sinularia flexibilis (Quoy and Gaimard), collected from the southern coast of Taiwan, led to the isolation of 10 new cembrenoid diterpenoids, the flexilarins A-J (1-10), along with 17 known compounds (11-27). The structures of these compounds were elucidated by spectroscopic techniques (NMR, MS, UV, IR). The structure of compound I was confirmed by X-ray crystallographic analysis. Compound 4 exhibited potent cytotoxicity against Hep2 tumor cells. (C) 2009 Published by Elsevier Ltd.

引用

页码：9157 / 9164

页数：8

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