Expression of nk2.1a during early development of the thyroid gland in zebrafish

被引：69

作者：

Rohr, KB ^{[1
]}

Concha, ML ^{[1
]}

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 95卷 / 1-2期

基金：

英国惠康基金;

关键词：

thyroid development; TTF-1; nk2.1; Titf-1; fate map; photoactivated fluorescein;

D O I：

10.1016/S0925-4773(00)00345-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We show here that a zebrafish orthologue of the Thyroid Transcription Factor-1 (TTF-1), nk2.1a, is expressed in the developing thyroid gland. Using a fate mapping approach we found that an early nk2.1a expression domain in the endoderm adjacent to the heart follows morphogenetic movements of the lower jaw, ending up in the region in which the mature thyroid gland is located. We therefore suggest that nk2.1a labels the thyroid precursor cells from somitogenesis stages onwards. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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页码：267 / 270

页数：4

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