Nectin and afadin: novel organizers of intercellular junctions

被引：477

作者：

Takai, Y ^{[1
]}

Nakanishi, H ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF CELL SCIENCE | 2003年 / 116卷 / 01期

关键词：

nectin; afadin; adherens junctions; tight junctions; puncta adherentia junctions; Sertoli-cell-spermatid junctions;

D O I：

10.1242/jcs.00167

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca2+-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis.

引用

页码：17 / 27

页数：11

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