Polymorphisms Associated with Both Noncardioembolic Stroke and Coronary Heart Disease: Vienna Stroke Registry

被引:25
作者
Luke, May M. [1 ]
Lalouschek, Wolfgang [2 ]
Rowland, Charles M. [1 ]
Catanese, Joseph J. [1 ]
Bolonick, Joel I. [1 ]
Bui, Nam D. [1 ]
Greisenegger, Stefan [3 ]
Endler, Georg [4 ]
Devlin, James J. [1 ]
Mannhalter, Christine [4 ]
机构
[1] Celera, Alameda, CA 94502 USA
[2] Hosp Barmherzige Brueder, Dept Neurol, Vienna, Austria
[3] Univ Clin Neurol, Vienna, Austria
[4] Med Univ Vienna, Inst Clin, Med & Chem Lab Diagnost, Vienna, Austria
基金
奥地利科学基金会;
关键词
Single nucleotide polymorphisms; Coronary heart disease; Stroke; Risk factors; Genetics; SINGLE-NUCLEOTIDE POLYMORPHISMS; COMMON GENE VARIANTS; ISCHEMIC-STROKE; MYOCARDIAL-INFARCTION; CHROMOSOME; 9P21; RISK; SUBTYPES; CLASSIFICATION;
D O I
10.1159/000236914
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Noncardioembolic stroke and coronary heart disease (CHD) may share genetic predispositions. We tested the hypothesis that genetic variants which are associated with risk of CHD would also be associated with risk of noncardioembolic stroke in 562 cases from the Vienna Stroke Registry and 815 controls. We selected 6 gene variants that had been consistently associated with risk of CHD in 3 studies, including the Atherosclerosis Risk in Communities study, and found that 4 of these gene variants were also associated with risk of noncardioembolic stroke. The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1.50) for rs10757274 on chromosome 9p21. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:499 / 504
页数:6
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