Mitochondria get a Parkin' ticket

被引：42

作者：

Wild, Philipp ^{[1
]}

Dikic, Ivan

机构：

[1] Goethe Univ Frankfurt, Sch Med, Inst Biochem 2, D-60590 Frankfurt, Germany

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 02期

关键词：

SELECTIVE AUTOPHAGY; UBIQUITIN; MITOPHAGY; PROTEIN; ATG32;

D O I：

10.1038/ncb0210-104

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

引用

页码：104 / 106

页数：4

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