Discrimination and dialogue in the immune system

被引：75

作者：

Cohen, IR ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

autoimmunity; maintenance; inflammation; self; homunculus;

D O I：

10.1006/smim.2000.0234

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper presents reasons for concluding that the immune system maintains the individual body throughout the vicissitudes of life without the need to make an absolute distinction between self and nonself: Self-maintenance and defence against parasites both require measured inflammation, and the immune system, in both its innate and adaptive arms, regulates inflammation. The intensity, dynamics and orchestration of inflammation emerge from an ongoing dialogue.

引用

页码：215 / 219

页数：5

共 28 条

[1] Immune information, self-organization and meaning [J].

Atlan, H ;

Cohen, IR .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (06) :711-717

[2] THE RAPID ISOLATION OF CLONABLE ANTIGEN-SPECIFIC LYMPHOCYTE-T LINES CAPABLE OF MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS [J].

BENNUN, A ;

WEKERLE, H ;

COHEN, IR .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1981, 11 (03) :195-199

[3] The 60-kDa heat shock protein modulates allograft rejection [J].

Birk, OS ;

Gur, SL ;

Elias, D ;

Margalit, R ;

Mor, F ;

Carmi, P ;

Bockova, J ;

Altmann, DM ;

Cohen, IR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5159-5163

[4]

Cohen I. R., 2000, TENDING ADAMS GARDEN, DOI DOI 10.1016/B978-012178355-6/50030-5

[5] THE COGNITIVE PARADIGM AND THE IMMUNOLOGICAL HOMUNCULUS [J].

COHEN, IR .

IMMUNOLOGY TODAY, 1992, 13 (12) :490-494

[6]

COHEN IR, 1995, CHEM IMMUNOL, V60, P150

[7] NON-ALUMINIC ADYNAMIC BONE-DISEASE IN NON-DIALYZED UREMIC PATIENTS - A NEW TYPE OF OSTEOPATHY DUE TO OVERTREATMENT [J].

COHENSOLAL, ME ;

SEBERT, JL ;

BOUDAILLIEZ, B ;

WESTEEL, PF ;

MORINIERE, PH ;

MARIE, A ;

GARABEDIAN, M ;

FOURNIER, A .

BONE, 1992, 13 (01) :1-5

[8] PEPTIDE THERAPY FOR DIABETES IN NOD MICE [J].

ELIAS, D ;

COHEN, IR .

LANCET, 1994, 343 (8899) :704-706

[9]

Fesel C, 1998, EUR J IMMUNOL, V28, P3616, DOI 10.1002/(SICI)1521-4141(199811)28:11&lt

[10]

3616::AID-IMMU3616&gt

← 1 2 3 →