The synthesis of L-aminosugar and the studies of L-pyranoses on the ring III of pyranmycins

被引：58

作者：

Wang, JH

Li, J

Tuttle, D

Takemoto, JY

Chang, CWT

机构：

[1] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA

[2] Utah State Univ, Dept Biol, Logan, UT 84322 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 23期

关键词：

D O I：

10.1021/ol026588r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The synthesis of a novel class of aminoglycoside, pyranmycin, and a convenient method for the preparation of 6-amino-L-idopyranosides were reported. One of the members in the reported pyranmycin families, TC010, has prominent activity against Escherichia coli, Staphylococcus aureus, and Bacillus megaterium. We also discovered that the C-4(1) chair conformation on ring III of pyranmycin is essential for the antibacterial activity.

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页码：3997 / 4000

页数：4

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