Protein-Functionalized Hairy Diamond Nanoparticles

被引：89

作者：

Dahoumane, Si Amar ^{[3
,4
]}

Nguyen, Minh Ngoc ^{[3
,4
]}

Thorel, Alain ^{[2
]}

Boudou, Jean-Paul ^{[1
]}

Chehimi, Mohamed M. ^{[3
,4
]}

Mangeney, Claire ^{[3
,4
]}

机构：

[1] Univ Evry Val Essonne, INSERM, U829, F-91025 Evry, France

[2] Mines ParisTech, Ctr Mat, F-91000 Evry, France

[3] Univ Paris Diderot, ITODYS, F-75013 Paris, France

[4] CNRS, UMR 7086, F-75013 Paris, France

来源：

LANGMUIR | 2009年 / 25卷 / 17期

关键词：

SURFACE FUNCTIONALIZATION; NANODIAMONDS; ATRP;

D O I：

10.1021/la9009509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diazonium salt chemistry and atom transfer radical polymerization (ATRP) were combined in view of preparing new bioactive hairy diamond nanoparticles containing, or potentially containing, nitrogen-vacancy (NV) fluorescent centers (fluorescent nanodiamonds, or fNDs). fNDs were modified by ATRP initiators using the electroless reduction of the diazonium salt BF4-,N-+(2)-C6H4-CH(CH3)-Br. The strongly bound aryl groups -C6H4-CH(CH3)-Br efficiently initiated the ATRP of tort-butyl methacrylate ((BMA) at the surface of the nanodiamonds, which resulted in obtaining ND-PtBMA hybrids. The grafted chain thickness, estimated from X-ray photoelectron spectroscopy (XPS), was found to increase linearly with respect to time before reaching a plateau value of ca. 2 nm. These nanoobjects were further hydrolyzed into ND-PMAA (where PMAA is the poly(methacrylic acid) graft) and further decorated by bovine serum albumin through the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling procedure.

引用

页码：9633 / 9638

页数：6

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