The origin and development of nonlymphoid tissue CD103+ DCs

被引:574
作者
Ginhoux, Florent [3 ,4 ,5 ]
Liu, Kang [1 ]
Helft, Julie [3 ,4 ]
Bogunovic, Milena [3 ,4 ]
Greter, Melanie [3 ,4 ]
Hashimoto, Daigo [3 ,4 ]
Price, Jeremy [3 ,4 ]
Yin, Na [3 ]
Bromberg, Jonathan [3 ]
Lira, Sergio A. [4 ]
Stanley, E. Richard [6 ]
Nussenzweig, Michel [1 ,2 ]
Merad, Miriam [3 ,4 ]
机构
[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA
[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA
[3] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA
[4] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA
[5] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore
[6] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA
基金
美国国家卫生研究院;
关键词
DENDRITIC CELL-DEVELOPMENT; BLOOD MONOCYTE SUBSETS; PERIPHERAL LYMPHOID ORGANS; EPIDERMAL LANGERHANS CELLS; NATURAL-KILLER-CELLS; IN-VIVO; TARGETED DISRUPTION; CROSS-PRESENTATION; STEADY-STATE; BONE-MARROW;
D O I
10.1084/jem.20091756
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c(+)MHCII(+) cells in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program.
引用
收藏
页码:3115 / 3130
页数:16
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