Antibodies Induced by Dengue Virus Type 1 and 2 Envelope Domain III Recombinant Proteins in Monkeys Neutralize Strains with Different Genotypes

被引：18

作者：

Bernardo, Lidice ^{[1
]}

Fleitas, Osmel ^{[1
]}

Pavon, Alequis ^{[1
]}

Hermida, Lisset ^{[2
]}

Guillen, Gerardo ^{[2
]}

Guzman, Maria G. ^{[1
]}

机构：

[1] Pedro Kouri Trop Med Inst, Dept Virol, PAHO, WHO Collaborating Ctr Study Dengue & Its Vector, Havana, Cuba

[2] Ctr Genet Engn & Biotechnol, Havana 10600, Cuba

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 12期

关键词：

MONOCLONAL-ANTIBODIES; AMERICAN GENOTYPES; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; FUSION PROTEIN; GLYCOPROTEIN; EPITOPES; MICE; IMMUNOGENICITY; PATHOGENESIS;

D O I：

10.1128/CVI.00191-09

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.

引用

页码：1829 / 1831

页数：3

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