The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers

被引：127

作者：

Li, Qingning ^{[1
]}

Wang, Xuemei ^{[1
]}

Lu, Xiaohua ^{[2
]}

Tian, Honger ^{[3
]}

Jiang, Hui ^{[1
]}

Lv, Gang ^{[1
]}

Guo, Dadong ^{[1
]}

Wu, Chunhui ^{[1
]}

Chen, Baoan ^{[4
]}

机构：

[1] Southeast Univ, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Peoples R China

[2] Nanjing Univ Technol, Coll Chem & Chem Engn, Nanjing 210009, Peoples R China

[3] Southeast Univ, Sch Publ Hlth, Nanjing 210096, Peoples R China

[4] Southeast Univ, Zhongda Hosp, Dept Hematol, Nanjing 210009, Peoples R China

来源：

BIOMATERIALS | 2009年 / 30卷 / 27期

基金：

中国国家自然科学基金;

关键词：

Titanium dioxide whiskers; Titanium dioxide nanoparticles; Ultra violet irradiation; Photocatalysis; Cancer therapy; Drug delivery; PHOTODYNAMIC THERAPY; NANOPARTICLES; RESISTANCE; APOPTOSIS; INDUCTION; ANATASE; TIO2;

D O I：

10.1016/j.biomaterials.2009.05.015

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good biocompatibility of TiO2 Ws and noted better photocatalytic activity. In human hepatocarcinoma cells (SMMC-7721 cells), TiO2 WS can obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency, indicating TiO2 WS could produce an efficient drug delivery carrier effect importing DNR into target cells. Furthermore, its photocatalysis further led to the enhanced mortality of cancer cells under UV irradiation. These findings reveal that TiO2 Ws-based delivery of anticancer drugs represents a promising approach in cancer therapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4708 / 4715

页数：8

共 25 条

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