Synthesis of periphery-functionalized dendritic molecules using polylithiated dendrimers as starting material

被引:59
作者
Wijkens, P
Jastrzebski, JTBH
van der Schaaf, PA
Kolly, R
Hafner, A
van Koten, G
机构
[1] Univ Utrecht, Debye Inst, Dept Met Mediated Synth, NL-3584 CH Utrecht, Netherlands
[2] Ciba Specialty Chem, CH-4002 Basel, Switzerland
关键词
D O I
10.1021/ol0059100
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] A general method for the functionalization of Si-Cl terminated carbosilane dendritic molecules via organolithium or organomagnesium reagents is described. Quantitative exchange of the bromine atoms of 4-bromophenyl-functionalized dendrimers affords polylithiated species that are valuable starting materials for further functionalization, e.g., into pyridyl alcohols. The latter were successfully applied as catalyst precursors in a ruthenium-mediated ring-closure metathesis reaction.
引用
收藏
页码:1621 / 1624
页数:4
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