Lymphotoxin-β receptor mediates NEMO-independent NF-κB activation

被引：57

作者：

Saitoh, T

Nakano, H

Yamamoto, N

Yamaoka, S

机构：

[1] Tokyo Med & Dent Univ, Dept Mol Virol, Grad Sch Med, Bunkyo Ku, Tokyo 1138519, Japan

[2] Juntendo Univ, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1138421, Japan

[3] Japan Sci & Technol Corp, PRESTO, Precursory Res Embryon Sci & Technol, Shibuya Ku, Tokyo 1510053, Japan

来源：

FEBS LETTERS | 2002年 / 532卷 / 1-2期

关键词：

I kappa B kinase; lymphotoxin-beta receptor; nuclear factor-kappa B essential modulator; nuclear factor-kappa B; RelB;

D O I：

10.1016/S0014-5793(02)03622-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lymphotoxin-beta receptor (LTbetaR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-kappaB (NF-kappaB) through the IkappaB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-kappaB essential modulator (NEMO). We demonstrate here that the LTbetaR signaling to NF-kappaB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not ReIA subunits of NF-kappaB are found in the nuclear DNA binding complexes induced by the LTOR signaling. Our results thus disclose NEMO-independent NF-kappaB activation by LTbetaR. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：45 / 51

页数：7

相关论文

共 47 条

[1] Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice [J].

Alimzhanov, MB ;

Kuprash, DV ;

KoscoVilbois, MH ;

Luz, A ;

Turetskaya, RL ;

Tarakhovsky, A ;

Rajewsky, K ;

Nedospasov, SA ;

Pfeffer, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9302-9307

[2] Characterization of a mutant cell line that does not activate NF-kappa B in response to multiple stimuli [J].

Courtois, G ;

Whiteside, ST ;

Sibley, CH ;

Israel, A .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) :1441-1449

[3] A cytokine-responsive I kappa B kinase that activates the transcription factor NF-kappa B [J].

DiDonato, JA ;

Hayakawa, M ;

Rothwarf, DM ;

Zandi, E ;

Karin, M .

NATURE, 1997, 388 (6642) :548-554

[4] Discrete signaling regions in the lymphotoxin-β receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-κB pathways [J].

Force, WR ;

Glass, AA ;

Benedict, CA ;

Cheung, TC ;

Lama, J ;

Ware, CF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) :11121-11129

[5] The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues [J].

Fütterer, A ;

Mink, K ;

Luz, A ;

Kosco-Vilbois, MH ;

Pfeffer, K .

IMMUNITY, 1998, 9 (01) :59-70

[6] GM-CSF-induced in vivo expansion of splenic dendritic cells and their strong costimulation activity [J].

Hanada, K ;

Tsunoda, R ;

Hamada, H .

JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 60 (02) :181-190

[7] IKKα controls formation of the epidermis independently of NF-κB [J].

Hu, YL ;

Baud, V ;

Oga, T ;

Kim, KII ;

Yoshida, K ;

Karin, M .

NATURE, 2001, 410 (6829) :710-714

[8] Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region [J].

Ishida, T ;

Mizushima, S ;

Azuma, S ;

Kobayashi, N ;

Tojo, T ;

Suzuki, K ;

Aizawa, S ;

Watanabe, T ;

Mosialos, G ;

Kieff, E ;

Yamamoto, T ;

Inoue, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) :28745-28748

[9] RelB-p50 NF-κB complexes are selectively induced by cytomegalovirus immediate-early protein 1:: Differential regulation of Bcl-xL promoter activity by NF-κB family members [J].

Jiang, HY ;

Petrovas, C ;

Sonenshein, GE .

JOURNAL OF VIROLOGY, 2002, 76 (11) :5737-5747

[10] NF-κB at the crossroads of life and death [J].

Karin, M ;

Lin, A .

NATURE IMMUNOLOGY, 2002, 3 (03) :221-227

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