Lymphotoxin-β receptor mediates NEMO-independent NF-κB activation

被引：57

作者：

Saitoh, T

Nakano, H

Yamamoto, N

Yamaoka, S

机构：

[1] Tokyo Med & Dent Univ, Dept Mol Virol, Grad Sch Med, Bunkyo Ku, Tokyo 1138519, Japan

[2] Juntendo Univ, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1138421, Japan

[3] Japan Sci & Technol Corp, PRESTO, Precursory Res Embryon Sci & Technol, Shibuya Ku, Tokyo 1510053, Japan

来源：

FEBS LETTERS | 2002年 / 532卷 / 1-2期

关键词：

I kappa B kinase; lymphotoxin-beta receptor; nuclear factor-kappa B essential modulator; nuclear factor-kappa B; RelB;

D O I：

10.1016/S0014-5793(02)03622-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lymphotoxin-beta receptor (LTbetaR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-kappaB (NF-kappaB) through the IkappaB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-kappaB essential modulator (NEMO). We demonstrate here that the LTbetaR signaling to NF-kappaB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not ReIA subunits of NF-kappaB are found in the nuclear DNA binding complexes induced by the LTOR signaling. Our results thus disclose NEMO-independent NF-kappaB activation by LTbetaR. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：45 / 51

页数：7

共 47 条

[21] Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I [J].