Unleashing formins to remodel the actin and microtubule cytoskeletons

被引：396

作者：

Chesarone, Melissa A. ^{[1
]}

DuPage, Amy Grace ^{[1
]}

Goode, Bruce L. ^{[1
]}

机构：

[1] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DIAPHANOUS-RELATED FORMIN; SRC TYROSINE KINASE; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; HOMOLOGY-2; DOMAIN; F-ACTIN; AUTOREGULATORY DOMAIN; FILAMENT ELONGATION; MITOTIC SPINDLE; RHO-GTPASES;

D O I：

10.1038/nrm2816

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formins are highly conserved proteins that have essential roles in remodelling the actin and microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work has identified numerous cellular factors that locally recruit, activate or inactivate formins to bridle and unleash their potent effects on actin nucleation and elongation. The effects of formins on microtubules have also begun to be described, which places formins in a prime position to coordinate actin and microtubule dynamics. The emerging complexity in the mechanisms governing formins mirrors the wide range of essential functions that they perform in cell motility, cell division and cell and tissue morphogenesis.

引用

页码：62 / 74

页数：13

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