Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon

被引：187

作者：

Jo, Sang Kyung ^{[1
]}

Rosner, Mitchell H. ^{[1
]}

Okusa, Mark D. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Charlottesville, VA USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 2卷 / 02期

关键词：

D O I：

10.2215/CJN.03280906

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This review describes past failures and barriers to successful clinical trials. It also focuses on promising preclinical studies using novel compounds that currently are in or close to human investigation. Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder.

引用

页码：356 / 365

页数：10

共 116 条

[111] EVIDENCE SUGGESTING A ROLE FOR HYDROXYL RADICAL IN GENTAMICIN-INDUCED ACUTE RENAL-FAILURE IN RATS [J].