Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

被引：293

作者：

Malik, S ^{[1
]}

Roeder, RG ^{[1
]}

机构：

[1] Rockefeller Univ, Biochem & Mol Biol Lab, New York, NY 10021 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(00)01596-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel multiprotein complex has recently been identified as a coactivator for transcriptional control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits.

引用

页码：277 / 283

页数：7

共 51 条

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