Looking Forward in Pharmaceutical Process Chemistry

被引:50
作者
Davies, Ian W. [1 ]
Welch, Christopher J. [1 ]
机构
[1] Merck, Rahway, NJ 07065 USA
关键词
D O I
10.1126/science.1174501
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Core activities of process chemistry involve the synthesis of drug candidates at a scale that supports clinical evaluations and the creation of a manufacturing process that is safe, robust, and cost effective. Innovative problem solving has always been a key element in process chemistry and will be increasingly important for addressing emerging challenges in science, globalization, and commoditization. The acquisition and creation of platform chemical technologies that enable rapid problem solving through the use of high-throughput experimentation will continue to be an important focus going forward. Linking and deploying platforms throughout the discovery-development continuum is expected to enable drug discovery. Increasing collaboration with academia will also become more important for accessing technical solutions and providing the next generation of innovative problem solvers.
引用
收藏
页码:701 / 704
页数:4
相关论文
共 9 条
[1]  
[Anonymous], 1999, IBUPROFEN CRITICAL B
[2]   Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion [J].
Davies, Huw M. L. ;
Manning, James R. .
NATURE, 2008, 451 (7177) :417-424
[3]  
Desrosiers P.J., 2004, MOD DRUG DISCOV, P40
[4]   Chemical Process Research and Development in the 21st Century: Challenges, Strategies, and Solutions from a Pharmaceutical Industry Perspective [J].
Federsel, Hans-Jurgen .
ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (05) :671-680
[5]   Enzyme optimization: moving from blind evolution to statistical exploration of sequence-function space [J].
Fox, Richard J. ;
Huisman, Gjait W. .
TRENDS IN BIOTECHNOLOGY, 2008, 26 (03) :132-138
[6]   The advent and development of organocatalysis [J].
MacMillan, David W. C. .
NATURE, 2008, 455 (7211) :304-308
[7]   Unlocking the potential asymmetric hydrogenation at Merck [J].
Shultz, C. Scott ;
Krska, Shane W. .
ACCOUNTS OF CHEMICAL RESEARCH, 2007, 40 (12) :1320-1326
[8]   Microscale HPLC predicts preparative performance at millionfold scale [J].
Welch, Christopher J. ;
Sajonz, Peter ;
Spencer, Glenn ;
Leonard, William ;
Henderson, Derek ;
Schafer, Wes ;
Bemardoni, Frank .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2008, 12 (04) :674-677
[9]   Adsorbent screening using microplate spectroscopy for selective removal of colored impurities from active pharmaceutical intermediates [J].
Welch, Christopher J. ;
Leonard, William R. ;
Henderson, Derek W. ;
Domer, Benjamin ;
Childers, Karla Glaser ;
Chung, John Y. L. ;
Harmer, Frederick W. ;
Albaneze-Walker, Jennifer ;
Sajonz, Peter .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2008, 12 (01) :81-87