Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study

被引:218
作者
Tedeschi, G
Lundbom, N
Raman, R
Bonavita, S
Duyn, JH
Alger, JR
DiChiro, G
机构
[1] NIH, LAB DIAGNOST RADIOL RES, BETHESDA, MD 20892 USA
[2] UNIV CALIF LOS ANGELES, JONSSON COMPREHENS CANC CTR, BRAIN RES INST, DEPT RADIOL SCI, LOS ANGELES, CA 90024 USA
关键词
primary brain tumor; cerebral glioma; malignant degeneration; tumor recurrence; magnetic resonance spectroscopy; proton magnetic resonance spectroscopy imaging; choline;
D O I
10.3171/jns.1997.87.4.0516
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors tested the hypothesis that proton magnetic resonance spectroscopy (H-1-MRS) imaging can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of low-to high-grade malignant transformation or posttherapeutic recurrence. Twenty-seven patients with cerebral gliomas verified on histological examination were studied repeatedly with H-1-MRS imaging over a period of 3.5 years. At the time of each H-1-MRS imaging study, clinical examination, MR imaging, positron emission tomography with F-18-fluorodeoxyglucose, and biopsy findings (when available) were used to categorize each patient as having tither stable or progressive disease. Measures of the percentage changes in the choline (Cho) H-1-MRS imaging signal intensity between studies, which were obtained without knowledge of the clinical categorization, allowed the investigators to segregate the groups with a high degree of statistical significance. All progressive cases showed a Cho signal increase between studies of more than 45%, whereas all stable cases showed an elevation of less than 35%, no changer or even a decreased signal. The authors conclude that increased Cho levels coincide with malignant degeneration of cerebral gliomas and therefore may possibly be used as a supportive indicator of progression of these neoplasms.
引用
收藏
页码:516 / 524
页数:9
相关论文
共 60 条
[21]  
FULHAM MJ, 1996, TXB NUCL MED, P361
[22]  
FULHAM MJ, 1992, CLIN POSITRON EMISSI, P50
[23]   PROTON MR SPECTROSCOPY OF INTRACRANIAL TUMORS - INVIVO AND INVITRO STUDIES [J].
GILL, SS ;
THOMAS, DGT ;
VANBRUGGEN, N ;
GADIAN, DG ;
PEDEN, CJ ;
BELL, JD ;
COX, IJ ;
MENON, DK ;
ILES, RA ;
BRYANT, DJ ;
COUTTS, GA .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1990, 14 (04) :497-504
[24]   IDENTIFICATION OF EARLY RECURRENCE OF PRIMARY CENTRAL-NERVOUS-SYSTEM TUMORS BY [F-18] FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY [J].
GLANTZ, MJ ;
HOFFMAN, JM ;
COLEMAN, RE ;
FRIEDMAN, AH ;
HANSON, MW ;
BURGER, PC ;
HERNDON, JE ;
MEISLER, WJ ;
SCHOLD, SC .
ANNALS OF NEUROLOGY, 1991, 29 (04) :347-355
[25]   FDG-PET IN THE SELECTION OF BRAIN-LESIONS FOR BIOPSY [J].
HANSON, MW ;
GLANTZ, MJ ;
HOFFMAN, JM ;
FRIEDMAN, AH ;
BURGER, PC ;
SCHOLD, SC ;
COLEMAN, RE .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1991, 15 (05) :796-801
[26]   CORRELATION OF GLUCOSE CONSUMPTION AND TUMOR-CELL DENSITY IN ASTROCYTOMAS - A STEREOTAXIC PET STUDY [J].
HERHOLZ, K ;
PIETRZYK, U ;
VOGES, J ;
SCHRODER, R ;
HALBER, M ;
TREUER, H ;
STURM, V ;
HEISS, WD .
JOURNAL OF NEUROSURGERY, 1993, 79 (06) :853-858
[27]   INVIVO IMAGING OF GLUCOSE CONSUMPTION AND LACTATE CONCENTRATION IN HUMAN GLIOMAS [J].
HERHOLZ, K ;
HEINDEL, W ;
LUYTEN, PR ;
DENHOLLANDER, JA ;
PIETRZYK, U ;
VOGES, J ;
KUGEL, H ;
FRIEDMANN, G ;
HEISS, WD .
ANNALS OF NEUROLOGY, 1992, 31 (03) :319-327
[28]  
HOLZER T, 1993, J COMPUT ASSIST TOMO, V17, P681
[29]  
Jackson E. F., 1992, American Journal of Physiologic Imaging, V7, P146
[30]  
JAECKLE KA, 1991, NEUROLOGY CLIN PRACT, V2, P1008