Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family didemnidae

被引：20

作者：

Kobayashi, Hirotsugu

Ohashi, Jun'ichiro

Fujita, Tsuyoshi

Iwashita, Takashi

Nakao, Yoichi

Matsunaga, Shigeki ^{[1
]}

Fusetani, Nobuhiro

机构：

[1] Univ Tokyo, Lab Aquat Nat Prod Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Suntory Inst Bioorgan Res, Shimamoto, Osaka 6188503, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 04期

关键词：

D O I：

10.1021/jo062013m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.

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页码：1218 / 1225

页数：8

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