Why ''underpowered'' trials are not necessarily unethical

被引：75

作者：

Edwards, SJL ^{[1
]}

Lilford, RJ ^{[1
]}

Braunholtz, D ^{[1
]}

Jackson, J ^{[1
]}

机构：

[1] UNIV LEEDS,DEPT PHILOSOPHY,LEEDS,W YORKSHIRE,ENGLAND

来源：

LANCET | 1997年 / 350卷 / 9080期

关键词：

D O I：

10.1016/S0140-6736(97)02290-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：804 / 807

页数：4

共 26 条

[1] MEDICINE AND MATHEMATICS - STATISTICS AND ETHICS IN MEDICAL-RESEARCH .3. HOW LARGE A SAMPLE [J].

ALTMAN, DG .

BRITISH MEDICAL JOURNAL, 1980, 281 (6251) :1336-1338

[2] A COMPARISON OF RESULTS OF METAANALYSES OF RANDOMIZED CONTROL TRIALS AND RECOMMENDATIONS OF CLINICAL EXPERTS - TREATMENTS FOR MYOCARDIAL-INFARCTION [J].

ANTMAN, EM ;

LAU, J ;

KUPELNICK, B ;

MOSTELLER, F ;

CHALMERS, TC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (02) :240-248

[3] MUST CLINICAL-TRIALS BE LARGE - THE INTERPRETATION OF P-VALUES AND THE COMBINATION OF TEST-RESULTS [J].

BARNARD, GA .

STATISTICS IN MEDICINE, 1990, 9 (06) :601-614

[4]

Botros S., 1990, ETHICS LAW HLTH CARE, P9

[5] Large trials vs meta-analysis of smaller trials - How do their results compare? [J].

Cappelleri, JC ;

Ioannidis, JPA ;

Schmid, CH ;

deFerranti, SD ;

Aubert, M ;

Chalmers, TC ;

Lau, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (16) :1332-1338

[6]

CLAYTON DG, 1982, BRIT J CLIN PHARMACO, V13, P469

[7] SIZE OF TRIALS FOR EVALUATION OF ANTENATAL TESTS OF FETAL WELLBEING IN HIGH-RISK PREGNANCY [J].

DEBONO, M ;

FAWDRY, RDS ;

LILFORD, RJ .

JOURNAL OF PERINATAL MEDICINE, 1990, 18 (02) :77-87

[8] INCORPORATING VARIATIONS IN THE QUALITY OF INDIVIDUAL RANDOMIZED TRIALS INTO METAANALYSIS [J].

DETSKY, AS ;

NAYLOR, CD ;

OROURKE, K ;

MCGEER, AJ ;

LABBE, KA .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1992, 45 (03) :255-265

[9] SAMPLE-SIZE - HOW MANY PATIENTS ARE NECESSARY [J].

FAYERS, PM ;

MACHIN, D .

BRITISH JOURNAL OF CANCER, 1995, 72 (01) :1-9

[10] TOWARDS AN INTERNATIONAL REGISTER OF CANCER TRIALS - THE UKCCCR REGISTER OF UK TRIALS [J].

FAYERS, PM ;

ARMITAGE, T .

EUROPEAN JOURNAL OF CANCER, 1993, 29A (06) :907-912

← 1 2 3 →