Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function

被引：69

作者：

Marshman, E ^{[1
]}

Streuli, CH ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

BREAST CANCER RESEARCH | 2002年 / 4卷 / 06期

关键词：

breast cancer; insulin-like growth factor; insulin-like growth factor binding proteins; mammary gland;

D O I：

10.1186/bcr535

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.

引用

页码：231 / 239

页数：9

共 94 条

[1] TUMOR-MARKERS IN PATIENTS WITH ADVANCED BREAST-CANCER AS PROGNOSTICATORS - A PRELIMINARY-STUDY [J].

BHATAVDEKAR, JM ;

PATEL, DD ;

KARELIA, NH ;

VORA, HH ;

GHOSH, N ;

SHAH, NG ;

BALAR, DB ;

TRIVEDI, SN .

BREAST CANCER RESEARCH AND TREATMENT, 1994, 30 (03) :293-297

[2] Insulin like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast [J].

Bohlke, K ;

Cramer, DW ;

Trichopoulos, D ;

Mantzoros, CS .

EPIDEMIOLOGY, 1998, 9 (05) :570-573

[3] Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds [J].

Bonnette, SG ;

Hadsell, DL .

ENDOCRINOLOGY, 2001, 142 (11) :4937-4945

[4] INSULIN-LIKE GROWTH-FACTORS AND THEIR BINDING-PROTEINS IN PLASMA AND MILK AFTER GROWTH HORMONE-STIMULATED GALACTOPOIESIS IN NORMALLY LACTATING WOMEN [J].

BREIER, BH ;

MILSOM, SR ;

BLUM, WF ;

SCHWANDER, J ;

GALLAHER, BW ;

GLUCKMAN, PD .

ACTA ENDOCRINOLOGICA, 1993, 129 (05) :427-435

[5] INSULIN-LIKE GROWTH-FACTOR-BINDING PROTEIN-3 IS DECREASED IN EARLY-STAGE OPERABLE PREMENOPAUSAL BREAST-CANCER [J].

BRUNING, PF ;

VANDOORN, J ;

BONFRER, JMG ;

VANNOORD, PAH ;

KORSE, CM ;

LINDERS, TC ;

HART, AAM .

INTERNATIONAL JOURNAL OF CANCER, 1995, 62 (03) :266-270

[6] IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development [J].

Cao, YX ;

Bonizzi, G ;

Seagroves, TN ;

Greten, FR ;

Johnson, R ;

Schmidt, EV ;

Karin, M .

CELL, 2001, 107 (06) :763-775

[7]

Chan TW, 2001, CLIN CANCER RES, V7, P2545

[8] Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 [J].

Chapman, RS ;

Lourenco, PC ;

Tonner, E ;

Elint, DJ ;

Selbert, S ;

Takeda, K ;

Akira, S ;

Clarke, AR ;

Watson, CJ .

GENES & DEVELOPMENT, 1999, 13 (19) :2604-2616

[9] A novel role for IRF-1 as a suppressor of apoptosis [J].

Chapman, RS ;

Duff, EK ;

Lourenco, PC ;

Tonner, E ;

Flint, DJ ;

Clarke, AR ;

Watson, CJ .

ONCOGENE, 2000, 19 (54) :6386-6391

[10] Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone [J].

Clarke, RB ;

Howell, A ;

Anderson, E .

BRITISH JOURNAL OF CANCER, 1997, 75 (02) :251-257

← 1 2 3 4 5 6 7 8 9 10 →