Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function

被引：69

作者：

Marshman, E ^{[1
]}

Streuli, CH ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

BREAST CANCER RESEARCH | 2002年 / 4卷 / 06期

关键词：

breast cancer; insulin-like growth factor; insulin-like growth factor binding proteins; mammary gland;

D O I：

10.1186/bcr535

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.

引用

页码：231 / 239

页数：9

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