Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis

被引：43

作者：

Davies, J

Neth, O

Alton, E

Klein, N

Turner, M

机构：

[1] Natl Heart & Lung Inst, Imperial Coll, Dept Gene Therapy, London SW3 6LR, England

[2] Inst Child Hlth, Immunobiol Unit, London, England

来源：

LANCET | 2000年 / 355卷 / 9218期

关键词：

D O I：

10.1016/S0140-6736(00)02297-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have found that mannose-binding lectin binds to Burkholderia cepacia, an important pathogen in patients with cystic fibrosis, and leads to complement activation, but that this is not the case for Pseudomonas aeruginosa, the more common colonising organism in this disease. We suggest that patients with cystic fibrosis with mannose-binding-lectin deficiency will be at particular risk of B cepacia colonisation.

引用

页码：1885 / 1886

页数：2

共 5 条

[1] Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: cohort study [J].