Responsive polymers at the biology/materials science interface

被引:158
作者
Alexander, Cameron [1 ]
Shakesheff, Kevin M. [1 ]
机构
[1] Univ Nottingham, Sch Pharm, Div Adv Drug Delivery & Tissue Engn, Nottingham NG7 2RD, England
关键词
D O I
10.1002/adma.200502640
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Synthethic polymers can be prepared with features that combine many of the advantageous properties of natural materials, including environmental response. This research news article considers the different types of reponse that can be 'programmed in' to polymers and the applications that are developing as a consequence of the designed responses. In particular, we focus on two key applications at the biology/materials science interfaces; responsive drug delivery systems and 'smart' surfaces for cell culture and regenerative medicine.
引用
收藏
页码:3321 / 3328
页数:8
相关论文
共 72 条
[1]   Stimuli responsive polymers for biomedical applications [J].
Alarcón, CDH ;
Pennadam, S ;
Alexander, C .
CHEMICAL SOCIETY REVIEWS, 2005, 34 (03) :276-285
[2]   Prodrug activation gated by a molecular "OR" logic trigger [J].
Amir, RJ ;
Popkov, M ;
Lerner, RA ;
Barbas, CF ;
Shabat, D .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (28) :4378-4381
[3]   Self-immolative dendrimer biodegradability by multi-enzymatic triggering [J].
Amir, RJ ;
Shabat, D .
CHEMICAL COMMUNICATIONS, 2004, (14) :1614-1615
[4]   Stimuli-responsive polypeptide vesicles by conformation-specific assembly [J].
Bellomo, EG ;
Wyrsta, MD ;
Pakstis, L ;
Pochan, DJ ;
Deming, TJ .
NATURE MATERIALS, 2004, 3 (04) :244-248
[5]   Millimeter-scale self-assembly and its applications [J].
Boncheva, M ;
Bruzewicz, DA ;
Whitesides, GM .
PURE AND APPLIED CHEMISTRY, 2003, 75 (05) :621-630
[6]   Molecule-mimetic chemistry and mesoscale self-assembly [J].
Bowden, NB ;
Weck, M ;
Choi, IS ;
Whitesides, GM .
ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (03) :231-238
[7]   Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction [J].
Carlisle, RC ;
Etrych, T ;
Briggs, SS ;
Preece, JA ;
Ulbrich, K ;
Seymour, LW .
JOURNAL OF GENE MEDICINE, 2004, 6 (03) :337-344
[8]   Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery [J].
Chilkoti, A ;
Dreher, MR ;
Meyer, DE .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (08) :1093-1111
[9]   Controlled living ring-opening-metathesis polymerization by a fast-initiating ruthenium catalyst [J].
Choi, TL ;
Grubbs, RH .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (15) :1743-1746
[10]  
CHOI YK, 1992, INT J PHARM, V80, P9