A biocatalytic cascade for the conversion of fatty acids to fatty amines

被引：43

作者：

Citoler, Joan ^{[1
]}

Derrington, Sasha R. ^{[1
]}

Galman, James L. ^{[1
]}

Bevinakatti, Han ^{[2
]}

Turner, Nicholas J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England

[2] Nouryon, 10 Finderne Ave, Bridgewater, NJ 08807 USA

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 18期

基金：

欧洲研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

INDUSTRIAL APPLICATIONS; AMINATION; REDUCTASE; NITRILES; ALCOHOLS; ENZYMES; FUELS;

D O I：

10.1039/c9gc02260k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (omega-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C-6 to C-18, were successfully aminated obtaining conversions of up to 96%.

引用

收藏

页码：4932 / 4935

页数：4

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