Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Germany and activity of the ketolide telithromycin: Results from the PROTEKT surveillance study (1999-2000)

被引:13
作者
Reinert, RR
Rodloff, AC
Halle, E
Baer, W
Beyreiss, B
Seifert, H
Wichelhaus, TA
Maass, M
Mehl, M
机构
[1] Univ Hosp, Inst Med Microbiol, Natl Reference Ctr Streptococci, DE-52057 Aachen, Germany
[2] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect, Leipzig, Germany
[3] Charite, Inst Microbiol & Hyg, Berlin, Germany
[4] Carl Thiem Clin, Inst Med Microbiol, Cottbus, Germany
[5] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany
[6] Univ Frankfurt Hosp, Inst Med Microbiol, Frankfurt, Germany
[7] Med Univ Lubeck, Inst Med Microbiol & Hyg, D-23538 Lubeck, Germany
[8] Helios Hosp, Inst Infectiol & Microbiol, Berlin, Germany
关键词
PROTEKT; Germany; antimicrobial resistance; respiratory tract pathogens;
D O I
10.1159/000077889
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin (PROTEKT) longitudinal global surveillance study examines the antibacterial susceptibility of community-acquired respiratory pathogens. Methods and Results: Data from isolates collected in Germany in 1999-2000 in the PROTEKT study show that 8.3% of pneumococcal isolates (n=325) had reduced susceptibility to penicillin and 2.2% were fully resistant. Erythromycin resistance was 15.7% overall and particularly high in Leipzig (31.6%). All penicillin- and erythromycin-resistant strains were inhibited by telithromycin (MICless than or equal to0.5 mg/l) and linezolid (MICless than or equal to2 mg/l). beta-Lactamase was produced by 3.2% of Haemophilus influenzae (9/284) and 89.5% of Moraxella catarrhalis strains (111/124). All Streptococcus pyogenes isolates (n=87) were susceptible to penicillin, although 9.2% were resistant to macrolides. Conclusions: Penicillin resistance in Germany remains low; however, the prevalence of antimicrobial resistance among common respiratory pathogens is rising, particularly against macrolides. Continued surveillance is necessary to guide optimal empirical therapy, and new antimicrobials, like telithromycin, need to be developed with improved potency against target pathogens and low propensity for the development of resistance. Copyright (C) 2004 S. Karger AG, Basel.
引用
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页码:143 / 151
页数:9
相关论文
共 28 条
[21]   Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany [J].
Reinert, RR ;
Al-Lahham, A ;
Lemperle, M ;
Tenholte, C ;
Briefs, C ;
Haupts, S ;
Gerards, HH ;
Lütticken, R .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (01) :61-68
[22]   Antimicrobial resistance and type distribution of Streptococcus pneumoniae isolates causing systemic infections in Germany, 1992-1994 [J].
Reinert, RR ;
Queck, A ;
Kaufhold, A ;
Kresken, M ;
Lutticken, R .
CLINICAL INFECTIOUS DISEASES, 1995, 21 (06) :1398-1401
[23]   Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients with respiratory tract infections in Germany from 1998 to 1999.: Results of a National Surveillance Study [J].
Reinert, RR ;
Simic, S ;
Al-Lahham, A ;
Reinert, S ;
Lemperle, M ;
Lütticken, R .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (03) :1187-1189
[24]  
REINERT RR, 2001, 41 INT C ANT AG CHEM
[25]   Sensitivity to sparfloxacin and other antibiotics, of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis strains isolated from adult patients with community-acquired lower respiratory tract infections:: a European multicentre study [J].
Richard, MP ;
Aguado, AG ;
Mattina, R ;
Marre, R .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (02) :207-214
[26]  
Schito GC, 2000, J ANTIMICROB CHEMOTH, V46, P3
[27]   Antimicrobial resistance in respiratory tract pathogens: Results of an international surveillance study [J].
Thornsberry, C ;
Sahm, DF .
CHEMOTHERAPY, 2000, 46 :15-23
[28]  
2002, ARZTL PRAX, V54, P8