共 44 条
PlnTFDB:: an integrative plant transcription factor database
被引:316
作者:

Riano-Pachon, Diego Mauricio
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机构: Univ Potsdam, Dept Mol Biol, Inst Biochem & Biol, D-14476 Golm, Germany

Ruzicic, Slobodan
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机构: Univ Potsdam, Dept Mol Biol, Inst Biochem & Biol, D-14476 Golm, Germany

Dreyer, Ingo
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机构: Univ Potsdam, Dept Mol Biol, Inst Biochem & Biol, D-14476 Golm, Germany

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机构:
机构:
[1] Univ Potsdam, Dept Mol Biol, Inst Biochem & Biol, D-14476 Golm, Germany
[2] Max Planck Inst Mol Plant Physiol, Cooperat Res Grp, D-14476 Golm, Germany
关键词:
D O I:
10.1186/1471-2105-8-42
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Background: Transcription factors (TFs) are key regulatory proteins that enhance or repress the transcriptional rate of their target genes by binding to specific promoter regions (i.e. cis-acting elements) upon activation or de-activation of upstream signaling cascades. TFs thus constitute master control elements of dynamic transcriptional networks. TFs have fundamental roles in almost all biological processes ( development, growth and response to environmental factors) and it is assumed that they play immensely important functions in the evolution of species. In plants, TFs have been employed to manipulate various types of metabolic, developmental and stress response pathways. Cross-species comparison and identification of regulatory modules and hence TFs is thought to become increasingly important for the rational design of new plant biomass. Up to now, however, no computational repository is available that provides access to the largely complete sets of transcription factors of sequenced plant genomes. Description: PlnTFDB is an integrative plant transcription factor database that provides a web interface to access large ( close to complete) sets of transcription factors of several plant species, currently encompassing Arabidopsis thaliana (thale cress), Populus trichocarpa ( poplar), Oryza sativa ( rice), Chlamydomonas reinhardtii and Ostreococcus tauri. It also provides an access point to its daughter databases of a species-centered representation of transcription factors (OstreoTFDB, ChlamyTFDB, ArabTFDB, PoplarTFDB and RiceTFDB). Information including protein sequences, coding regions, genomic sequences, expressed sequence tags ( ESTs), domain architecture and scientific literature is provided for each family. Conclusion: We have created lists of putatively complete sets of transcription factors and other transcriptional regulators for five plant genomes. They are publicly available through http://plntfdb.bio.uni-potsdam.de. Further data will be included in the future when the sequences of other plant genomes become available.
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机构: Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China

Luo, JC
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机构: Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China

Deng, XW
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机构: Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China

Zhu, YX
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Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Beijing 100871, Peoples R China