Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

被引：19

作者：

Baxter, AD

Bhogal, R

Bird, JB

Buckley, GM

Gregory, DS

Hedger, PC

Manallack, DT

Massil, T

Minton, KJ

Montana, JG

Neidle, S

Owen, DA

Watson, RJ

机构：

[1] CHIROSCI LTD,CAMBRIDGE CB4 4WE,ENGLAND

[2] INST CANC RES,CRC,BIOMOL STRUCT UNIT,SUTTON SM2 5NG,SURREY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10069-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro potency of orally-active mercaptoacyl matrix metalloproteinase inhibitors is increased by the introduction of appropriate substituents on the mercaptoacyl moiety. (C) 1997 Elsevier Science Ltd.

引用

页码：2765 / 2770

页数：6

共 22 条

[1] A novel series of matrix metalloproteinase inhibitors for the treatment of inflammatory disorders
Baxter, AD
Bird, J
Bhogal, R
Massil, T
Minton, KJ
Montana, J
Owen, DA
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (07) : 897 - 902
[2] Recent advances in matrix metalloproteinase inhibitor research
Beckett, RP
Davidson, AH
Drummond, AH
Huxley, P
Whittaker, M
[J]. DRUG DISCOVERY TODAY, 1996, 1 (01) : 16 - 26
[3] SYNTHESIS OF THE POLYETHER ANTIBIOTIC MONENSIN .2. PREPARATION OF INTERMEDIATES
COLLUM, DB
MCDONALD, JH
STILL, WC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (06) : 2118 - 2120
[4] EMONARD H, 1990, CELL MOL BIOL, V36, P131
[5] METAL-BINDING PEPTIDE INHIBITORS OF VERTEBRATE COLLAGENASE
GRAY, RD
SANEII, HH
SPATOLA, AF
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 101 (04) : 1251 - 1258
[6] GUIDA WC, 1989, J AM CHEM SOC, V111, P4379
[7] HENDERSON B, 1990, Drugs of the Future, V15, P495
[8] Johnson W H, 1987, J Enzyme Inhib, V2, P1, DOI 10.3109/14756368709030352
[9] A NOVEL COUMARIN-LABELED PEPTIDE FOR SENSITIVE CONTINUOUS ASSAYS OF THE MATRIX METALLOPROTEINASES
KNIGHT, CG
WILLENBROCK, F
MURPHY, G
[J]. FEBS LETTERS, 1992, 296 (03): : 263 - 266
[10] AMBER-ASTERISK TORSIONAL PARAMETERS FOR THE PEPTIDE BACKBONE
MCDONALD, DQ
STILL, WC
[J]. TETRAHEDRON LETTERS, 1992, 33 (50) : 7743 - 7746

← 1 2 3 →