Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects An updated systematic review

被引:32
作者
Aminoshariae, Anita [1 ]
Kulild, James C. [2 ]
Donaldson, Mark [3 ,4 ,5 ]
机构
[1] Case Western Reserve Univ, Predoctoral Endodont, Sch Dent Med, 2124 Cornell Rd, Cleveland, OH 44106 USA
[2] Univ Missouri, Sch Dent, Dept Endodont, Kansas City, MO USA
[3] VHA Clin Pharm, Performance Serv, Irving, TX USA
[4] Univ Montana, Sch Pharm, Missoula, MT 59812 USA
[5] Oregon Hlth & Sci Univ, Sch Dent, Portland, OR 97201 USA
关键词
NSAIDs; cardiovascular risk; myocardial infarction; gastrointestinal; renal; respiratory; randomized controlled clinical trials; cohort studies; case-controlled studies; vascular events; LOW-DOSE ASPIRIN; RECEIVING ANTITHROMBOTIC THERAPY; EXACERBATED RESPIRATORY-DISEASE; SELECTIVE COX-2 INHIBITOR; RENAL-FUNCTION; MYOCARDIAL-INFARCTION; DOUBLE-BLIND; GASTROINTESTINAL TOLERABILITY; CYCLOOXYGENASE-2; INHIBITOR; ACETYLSALICYLIC-ACID;
D O I
10.1016/j.adaj.2015.07.020
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background. In this article, the authors examine the available scientific evidence regarding adverse effects of short-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Short-term use was defined as 10 days or fewer. Methods. The authors reviewed randomized controlled clinical trials and cohort and case-controlled clinical studies published between 2001 and June 2015 in which the investigators reported on the safety of nonselective cyclooxygenase inhibitors and of cyclooxygenase-2 selective inhibitor NSAIDs. Results. The systematic review process according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines allowed the authors to identify 40 studies that met the inclusion criteria. Conclusions. On the basis of the available scientific evidence, NSAIDs may be considered relatively safe drugs when prescribed at the most effective dose and for the shortest duration of time, which was defined to be 10 days or fewer.
引用
收藏
页码:98 / 110
页数:13
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