Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder

被引:224
作者
Kowatch, RA
Suppes, T
Carmody, TJ
Bucci, JP
Hume, JH
Kromelis, M
Emslie, GJ
Weinberg, WA
Rush, AJ
机构
[1] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Dept Neurol, Dallas, TX 75235 USA
[3] Univ Texas, SW Med Ctr, Dept Biostat, Dallas, TX 75235 USA
[4] Childrens Med Ctr, Dallas, TX 75235 USA
关键词
bipolar disorder; effect size; lithium; carbamazepine; divalproex sodium;
D O I
10.1097/00004583-200006000-00009
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: To develop effect sizes for 3 mood stabilizers-lithium. divalproex sodium, and carbamazepine-for the acute-phase treatment of bipolar I or II disorder, mixed or manic episode, in children and adolescents aged 8 to 18 years. Method: Forty-two outpatients with a mean age of 11.4 years (20 with bipolar I disorder and 22 with bipolar II disorder) were randomly assigned to 6 weeks of open treatment with either lithium, divalproex sodium, or carbamazepine. The primary efficacy measures were the weekly Clinical Global Impression Improvement scores and the Young Mania Rating Scale (Y-MRS). Results: Using a greater than or equal to 50% change from baseline to exit in the Y-MRS scores to define response, the effect size was 1.63 for divalproex sodium, 1.06 for lithium, and 1.00 for carbamazepine. Using this same response measure with the intent-to-treat sample, the response rates were as follows: sodium divalproex, 53%; lithium, 38%; and carbamazepine, 38% (chi(2)(2) = 0.85, p = .60). All 3 mood stabilizers were well tolerated. and no serious adverse effects were seen. Conclusions: Divalproex sodium, lithium, and carbamazepine all showed a large effect size in the open treatment of children and adolescents with bipolar I or II disorder in a mixed or manic episode.
引用
收藏
页码:713 / 720
页数:8
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