Vanadium-catalyzed asymmetric cyanohydrin synthesis

被引：150

作者：

Belokon, YN

North, M ^{[1
]}

Parsons, T

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

[2] Russian Acad Sci, Inst Organoelement Cpds, Moscow 117813, Russia

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 11期

关键词：

D O I：

10.1021/ol005893e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Based on a mechanistic understanding of asymmetric cyanohydrin synthesis catalyzed by chiral titanium-salen complexes, a new catalyst based on vanadlum(IV) has been developed. The chiral (salen)VO catalyst is more enantioselective than the titanium based systems, 0.1 mol % of the catalyst being sufficient to convert aromatic and aliphatic aldehydes into the corresponding trimethylsilyl ethers of cyanohydrins with 68-95% enantiomeric excess at room temperature.

引用

页码：1617 / 1619

页数：3

共 22 条

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