X=Y-ZH systems as potential 1,3-dipoles .47. Tandem nucleophilic substitution-1,3 dipolar cycloaddition reactions of oximes with epoxides and dipolarophiles

被引：31

作者：

Markandu, J ^{[1
]}

Dondas, HA ^{[1
]}

Frederickson, M ^{[1
]}

Grigg, R ^{[1
]}

机构：

[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(97)00838-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regiospecific nucleophilic substitution reactions involving attack of the nitrogen atom of oximes on epoxides are used to generate nitrones which are then trapped in 1,3-dipolar cycloaddition reactions. These tandem processes are shown to be flexible and to have wide synthetic scope for the construction of complex molecular frameworks. (C) 1997 Elsevier Science Ltd.

引用

页码：13165 / 13176

页数：12

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