Is there a neuropathology of schizophrenia? Recent findings converge on altered thalamic-prefrontal cortical connectivity

被引:43
作者
Lewis, DA
机构
[1] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15213 USA
关键词
schizophrenia; prefrontal cortex; mediodorsal thalamus; dopamine; GABA; pyramidal neuron;
D O I
10.1177/107385840000600311
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Schizophrenia is a serious and chronic brain disorder whose underlying neuropathology has proven difficult to identify. This article reviews the current status of neuropathological studies in terms of how they inform the diagnosis, pathogenesis, pathophysiology, and mechanisms of treatment of schizophrenia. Although additional studies are required, substantial data converge on the hypothesis that the pathophysiology of schizophrenia is associated with alterations in thalamic-prefrontal cortical connectivity.
引用
收藏
页码:208 / 218
页数:11
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