Orchestrating sleep-wake functions in the brain

被引：8

作者：

Hajak, G ^{[1
]}

Geisler, P ^{[1
]}

机构：

[1] Univ Regensburg, Dept Psychiat & Psychotherapy, D-8400 Regensburg, Germany

来源：

NATURE MEDICINE | 2003年 / 9卷 / 02期

关键词：

D O I：

10.1038/nm0203-170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Staying awake and alert requires hypothalamic neurons that secrete the neurotransmitter hypocretin, also called orexin. A new study shows that feedback loops of hypocretin and glutamate neurons orchestrate the neuronal output that regulates arousal.

引用

页码：170 / 171

页数：2

共 12 条

[1] Hypocretins/orexins as integrators of physiological information: lessons from mutant animals [J].

de Lecea, L ;

Sutcliffe, JG ;

Fabre, V .

NEUROPEPTIDES, 2002, 36 (2-3) :85-95

[2] Hypothalamic gray matter changes in narcoleptic patients [J].

Draganski, B ;

Geisler, P ;

Hajak, G ;

Schuierer, G ;

Bogdahn, U ;

Winkler, J ;

May, A .

NATURE MEDICINE, 2002, 8 (11) :1186-1188

[3] Sleep as a problem of localization [J].

Economo, CV .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1930, 71 :249-259

[4] Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - A potential mechanism for orchestrating the hypothalamic arousal system [J].

Li, Y ;

Gao, XB ;

Sakurai, T ;

van den Pol, AN .

NEURON, 2002, 36 (06) :1169-1181

[5] Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors [J].

Mieda, M ;

Yanagisawa, M .

CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (03) :339-345

[6] Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders [J].

Mignot, E ;

Taheri, S ;

Nishino, S .

NATURE NEUROSCIENCE, 2002, 5 (Suppl 11) :1071-1075

[7] Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy [J].

Overeem, S ;

Scammell, TW ;

Lammers, GJ .

CURRENT OPINION IN NEUROLOGY, 2002, 15 (06) :739-745

[8] Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives [J].

Overeem, S ;

Mignot, E ;

van Dijk, JG ;

Lammers, GJ .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2001, 18 (02) :78-105

[9] Neuronal effects of orexins: relevant to sympathetic and cardiovascular functions [J].

Shirasaka, T ;

Kunitake, T ;

Takasaki, M ;

Kannan, H .

REGULATORY PEPTIDES, 2002, 104 (1-3) :91-95

[10] The hypocretins: Setting the arousal threshold [J].

Sutcliffe, JG ;

de Lecea, L .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (05) :339-349

← 1 2 →