Vitamin D, the immune system and asthma

被引：101

作者：

Lange, Nancy E. ^{[1
]}

Litonjua, Augusto ^{[1
]}

Hawrylowicz, Catherine M. ^{[2
]}

Weiss, Scott ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Channing Lab, Div Pulm & Crit Care Med, Boston, MA 02115 USA

[2] Kings Coll London, Guys Hosp, Dept Asthma Allergy & Resp Sci, London SE1 9RT, England

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2009年 / 5卷 / 06期

关键词：

asthma; autoimmune disease; immune system regulation; T-regulatory cell; vitamin D; vitamin D deficiency; REGULATORY T-CELLS; RESPIRATORY SYNCYTIAL VIRUS; 3RD NATIONAL-HEALTH; SERUM 25-HYDROXYVITAMIN-D LEVELS; BONE-MINERAL DENSITY; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; NUTRITIONAL RICKETS; DENDRITIC CELLS;

D O I：

10.1586/ECI.09.53

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of vitamin D on bone metabolism and calcium homeostasis have long been recognized. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been found to be associated with several immune-mediated diseases, susceptibility to infection and cancer. Recently, there has been increasing interest in the possible link between vitamin D and asthma. Further elucidation of the role of vitamin D in lung development and immune system function may hold profound implications for the prevention and treatment of asthma.

引用

页码：693 / 702

页数：10

共 142 条

[1] Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity [J].

Adams, John S. ;

Hewison, Martin .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2008, 4 (02) :80-90

[2] Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands [J].

Adorini, L ;

Penna, G ;

Giarratana, N ;

Roncari, A ;

Amuchastegui, S ;

Daniel, KC ;

Uskokovic, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 89-90 (1-5) :437-441

[3]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[4]

Aligne CA, 2000, AM J RESP CRIT CARE, V162, P873

[5]

Aloia JF, 2007, EPIDEMIOL INFECT, V135, P1095, DOI 10.1017/S0950268807008308

[6]

[Anonymous], AM J EPIDEMIOLOGY

[7] Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells [J].

Banerjee, A. ;

Damera, G. ;

Bhandare, R. ;

Gu, S. ;

Lopez-Boado, Y. S. ;

Panettieri, R. A., Jr. ;

Tliba, O. .

BRITISH JOURNAL OF PHARMACOLOGY, 2008, 155 (01) :84-92

[8] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[9] Overweight, obesity, and incident asthma - A meta-analysis of prospective epidemiologic studies [J].

Beuther, David A. ;

Sutherland, E. Rand .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (07) :661-666

[10]

Bhattacharyya A K, 1992, World Rev Nutr Diet, V67, P140

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