Vitamin D, the immune system and asthma

被引：101

作者：

Lange, Nancy E. ^{[1
]}

Litonjua, Augusto ^{[1
]}

Hawrylowicz, Catherine M. ^{[2
]}

Weiss, Scott ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Channing Lab, Div Pulm & Crit Care Med, Boston, MA 02115 USA

[2] Kings Coll London, Guys Hosp, Dept Asthma Allergy & Resp Sci, London SE1 9RT, England

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2009年 / 5卷 / 06期

关键词：

asthma; autoimmune disease; immune system regulation; T-regulatory cell; vitamin D; vitamin D deficiency; REGULATORY T-CELLS; RESPIRATORY SYNCYTIAL VIRUS; 3RD NATIONAL-HEALTH; SERUM 25-HYDROXYVITAMIN-D LEVELS; BONE-MINERAL DENSITY; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; NUTRITIONAL RICKETS; DENDRITIC CELLS;

D O I：

10.1586/ECI.09.53

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of vitamin D on bone metabolism and calcium homeostasis have long been recognized. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been found to be associated with several immune-mediated diseases, susceptibility to infection and cancer. Recently, there has been increasing interest in the possible link between vitamin D and asthma. Further elucidation of the role of vitamin D in lung development and immune system function may hold profound implications for the prevention and treatment of asthma.

引用

页码：693 / 702

页数：10

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