Compaction and folding in model proteins

被引：5

作者：

Chiu, TL

Goldstein, RA

机构：

[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,DIV BIOPHYS RES,ANN ARBOR,MI 48109

来源：

JOURNAL OF CHEMICAL PHYSICS | 1997年 / 107卷 / 11期

关键词：

D O I：

10.1063/1.474782

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Protein folding is modeled as diffusion on a free-energy landscape, allowing use of the diffusion equation to study the impact of energetic parameters on the folding dynamics. The free-energy landscape is characterized by two different order parameters, one representing the degree of compactness, the other a measure of the progress towards the folded state. For marginally stable proteins, fastest folding is achieved when the nonspecific interactions favoring compaction are strong, resulting in a high folding temperature. Such proteins fold by rapid collapse followed by slower accumulation of correct contacts. (C) 1997 American Institute of Physics.

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页码：4408 / 4415

页数：8

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