Novel method for rapid, simultaneous T1, T2*, and proton density quantification

被引:191
作者
Warntjes, J. B. M. [1 ]
Dahlqvist, O.
Lundberg, P.
机构
[1] Linkoping Univ, Ctr Med Imaging & Visualizat, SE-58185 Linkoping, Sweden
[2] Linkoping Univ, Dept Med & Care, Div Clin Physiol, SE-58185 Linkoping, Sweden
[3] Linkoping Univ, Dept Med & Care, Div Radiat Phys, SE-58185 Linkoping, Sweden
[4] Linkoping Univ Hosp, Dept Radiat Phys, S-58185 Linkoping, Sweden
关键词
T-1; mapping; T-2(*) mapping; proton density mapping; quantitative MRI; rapid quantification;
D O I
10.1002/mrm.21165
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];
摘要
An imaging method called "quantification of relaxation times and proton density by twin-echo saturation-recovery turbo-field echo" (ORAPTEST) is presented as a means of quickly determining the longitudinal T-1 and transverse T-2* relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B, field inhomogeneity. High-resolution images covering large volumes can be achieved within clinically acceptable times of 5-10 min. The range of accuracy for determining T-1, T-2*, and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm(3) voxels was achieved in less than 8 min.
引用
收藏
页码:528 / 537
页数:10
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