Recent advances in the genetics of autism

被引：122

作者：

Gupta, Abha R.

State, Matthew W.

机构：

[1] Yale Univ, Sch Med, Child Study Ctr, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

来源：

BIOLOGICAL PSYCHIATRY | 2007年 / 61卷 / 04期

关键词：

association; autism spectrum disorder; candidate genes; cytogenetics; genetics; linkage;

D O I：

10.1016/j.biopsych.2006.06.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism is a strongly genetic disorder with an estimated heritability of greater than. 90%. Nonetheless, its specific genetic etiology remains largely unknown. Over the past several years, the convergence of rapidly advancing genomic technologies, the completion to the human genome project, and succesful collaborative efforts to increase the number of deoxyribonucleic acid samples available for study have led to the first solid clues regarding the genetic origins of autism spectrum disorders. This article addresses the obstacles that have confronted gene discovery efforts and reviews recent linkage, cytogenetic, and candidate gene association studies relevant to autism, spectrum disorders. In addition, promising avenues for future research and the potential contribution of emerging genomic technologies are considered.

引用

页码：429 / 437

页数：9

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