Presynaptic hyperexcitability at cerebellar synapses in traumatic injury rat

被引：22

作者：

Ai, JL ^{[1
]}

Baker, A ^{[1
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Trauma Brain Injury Lab, Cara Phelan Ctr Trauma Res, Toronto, ON M5B 1W8, Canada

来源：

NEUROSCIENCE LETTERS | 2002年 / 332卷 / 03期

基金：

加拿大健康研究院;

关键词：

cerebellum; neurotransmission; presynaptic; hyperexcitability; trauma brain injury;

D O I：

10.1016/S0304-3940(02)00945-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotransmission in rat cerebellum following fluid percussion injury (FPI) was studied by extracellular recording method. An increased amplitude of population spikes from presynaptic mossy fibers was detected at 3 days after FPI. However, there were no differences at 1 h, 1 day, 1 week or 2 weeks after FPI compared to naive controls. An enhanced amplitude of the population spikes, as well as the after hyperpolarization component from presynaptic response of the parallel fibers, was seen in the groups at 3 days and 1 week post FPI, but not in other groups. These results indicate a presynaptic hyperexcitation was induced by FPI within a specific time window. This hyperexcitability may contribute to the reported loss of Purkinje cells after FPI. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 158

页数：4

共 17 条

[1] Long-term potentiation of intrinsic excitability at the Mossy fiber-granule cell synapse of rat cerebellum [J].