Surveillance of HIV Type 1 Drug Resistance among Naive Patients from Venezuela

被引：10

作者：

Castillo, Julio ^{[2
]}

Comegna, Mario ^{[3
]}

Quijada, Wilmary ^{[2
]}

Jauvin, Valerie ^{[4
]}

Pinson, Patricia ^{[4
]}

Masquelier, Bernard ^{[4
]}

Fleury, Herve ^{[4
]}

Castro, Erika ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Hosp Univ Vaudois, Div Immunol & Allergy, Lab AIDS Immunopathogenesis, CH-1011 Lausanne, Switzerland

[2] Cent Univ Venezuela, Dept Internal Med, Vargas Hosp, Caracas, Venezuela

[3] Cent Univ Venezuela, Dept Infect Dis, Vargas Hosp, Caracas, Venezuela

[4] Univ Bordeaux, Lab Virol EA 2968, Bordeaux, France

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2009年 / 25卷 / 12期

关键词：

BLOOD MONONUCLEAR-CELLS; MOLECULAR EPIDEMIOLOGY; MUTATIONS; IDENTIFICATION; PLASMA; HAART;

D O I：

10.1089/aid.2009.0118

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have studied 65 HIV-1-infected untreated patients recruited in Caracas, Venezuela with TCD4 counts >= 350/mu l. The reverse transcriptase and protease sequences of the virus were sequenced, aligned with reference HIV-1 group M strains, and analyzed for drug resistance mutations. Most of the viruses were subtype B genotype in both the protease and RT genomic regions. Five of the 62 virus isolates successfully amplified showed evidence of recombination between protease and RT, with their protease region being non-B while their RT region was derived from subtype B. Four strains were found bearing resistance mutations either to NRTIs, NNRTIs, or PIs. The prevalence of HIV-1 isolates bearing resistance mutations was therefore above the 5% threshold of WHO.

引用

页码：1329 / 1333

页数：5

共 13 条

[1]

Bennett DE, 2008, ANTIVIR THER, V13, P1

[2] HIV type 1 drug resistance among naive patients from Venezuela [J].

Bouchard, Morella ;

Masquelier, Bernard ;

Moreno, Melcenia ;

Deibis, Leopoldo ;

De Perez, Gloria Echeverria ;

Fleury, Herve ;

Castro, Erika .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (03) :482-485

[3] Trends of HIV-1 molecular epidemiology in Venezuela:: introduction of subtype C and identification of a novel B/C mosaic genome [J].

Castro, E ;

Moreno, M ;

Deibis, L ;

de Pérez, G ;

Salmen, S ;

Berrueta, L .

JOURNAL OF CLINICAL VIROLOGY, 2005, 32 (03) :257-258

[4] Molecular epidemiology of HIV-1 in Venezuela:: High prevalence of HIV-1 subtype B and identification of a B/F recombinant infection [J].

Castro, E ;

Echeverría, G ;

Deibis, L ;

de Salmen, BG ;

Moreira, AD ;

Guimaraes, ML ;

Bastos, FI ;

Morgado, MG .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 32 (03) :338-344

[5] Assessment of drug resistance mutations in plasma and peripheral blood mononuclear cells at different plasma viral loads in patients receiving HAART [J].

Chew, CB ;

Potter, SJ ;

Wang, B ;

Wang, YM ;

Shaw, CO ;

Dwyer, DE ;

Saksena, NK .

JOURNAL OF CLINICAL VIROLOGY, 2005, 33 (03) :206-216

[6] Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification:: A UNAIDS study [J].

Delgado, E ;

León-Ponte, M ;

Villahermosa, ML ;

Cuevas, MT ;

Deibis, L ;

Echeverría, G ;

Thomson, MM ;

Pérez-Alvarez, L ;

Osmanov, S ;

Nájera, R .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (08) :753-758

[7] Resistance mutations in subtype CHIV type 1 isolates from Indian patients of mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: Resistance to AR [J].

Deshpande, Alaka ;

Jauvin, Valerie ;

Magnin, Noel ;

Pinson, Patricia ;

Faure, Muriel ;

Masquelier, Bernard ;

Aurillac-Lavignolle, Valerie ;

Fleury, Herve J. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (02) :335-340

[8] Substantial correlation between HIV type 1 drug-associated resistance mutations in plasma and peripheral blood mononuclear cells in treatment-experienced patients [J].

Devereux, HL ;

Loveday, C ;

Youle, M ;

Sabin, CA ;

Burke, A ;

Johnson, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (11) :1025-1030

[9]

Dieudonne Mariacarolina, 2006, Invest. clín, V47, P27

[10] HIV type 1 diversity in France, 1999-2001: Molecular characterization of non-B HIV type 1 subtypes and potential impact on susceptibility to antiretroviral drugs [J].

Fleury, H ;

Recordon-Pinson, P ;

Caumont, A ;

Faure, M ;

Roques, P ;

Plantier, JC ;

Couturier, E ;

Dormont, D ;

Masquelier, B ;

Simon, F .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2003, 19 (01) :41-47

← 1 2 →