The journey of the malaria sporozoite through its hosts:: two parasite proteins lead the way

被引：53

作者：

Ménard, R ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10003 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 06期

关键词：

malaria; cell invasion; gliding motility; CS; TRAP;

D O I：

10.1016/S1286-4579(00)00362-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria is transmitted to a mammalian host when the sporozoite stage of the Plasmodium parasite is injected by a mosquito vector. Sporozoites are unique in being able to interact with both hosts. Formed and released in the mosquito midgut, sporozoites bind to the salivary glands and invade their secretory cells. Once injected into the mammalian host, they home to the liver and invade hepatocytes. Recent work has shown that two sporozoite surface proteins, CS and TRAP, act in both hosts,perform multiple functions, and are each essential for the parasite at more than one step of its life cycle. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：633 / 642

页数：10

共 62 条

[1] ERYTHROCYTE ENTRY BY MALARIAL PARASITES - MOVING JUNCTION BETWEEN ERYTHROCYTE AND PARASITE [J].

AIKAWA, M ;

MILLER, LH ;

JOHNSON, J ;

RABBEGE, J .

JOURNAL OF CELL BIOLOGY, 1978, 77 (01) :72-82

[2] IMMUNOFLUORESCENT MICROSCOPIC VISUALIZATION OF TRAILS LEFT BY GLIDING CRYPTOSPORIDIUM-PARVUM SPOROZOITES [J].

ARROWOOD, MJ ;

STERLING, CR ;

HEALEY, MC .

JOURNAL OF PARASITOLOGY, 1991, 77 (02) :315-317

[3]

Carruthers VB, 1997, EUR J CELL BIOL, V73, P114

[4] THE BASOLATERAL DOMAIN OF THE HEPATOCYTE PLASMA-MEMBRANE BEARS RECEPTORS FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SPOROZOITES [J].

CERAMI, C ;

FREVERT, U ;

SINNIS, P ;

TAKACS, B ;

CLAVIJO, P ;

SANTOS, MJ ;

NUSSENZWEIG, V .

CELL, 1992, 70 (06) :1021-1033

[5] RAPID CLEARANCE OF MALARIA CIRCUMSPOROZOITE PROTEIN (CS) BY HEPATOCYTES [J].

CERAMI, C ;

FREVERT, U ;

SINNIS, SP ;

TAKACS, B ;

NUSSENZWEIG, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) :695-701

[6] Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress [J].

Crabb, BS ;

Cooke, BM ;

Reeder, JC ;

Waller, RF ;

Caruana, SR ;

Davern, KM ;

Wickham, ME ;

Brown, GV ;

Coppel, RL ;

Cowman, AF .

CELL, 1997, 89 (02) :287-296

[7] STRUCTURE OF THE GENE ENCODING THE IMMUNODOMINANT SURFACE-ANTIGEN ON THE SPOROZOITE OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

DAME, JB ;

WILLIAMS, JL ;

MCCUTCHAN, TF ;

WEBER, JL ;

WIRTZ, RA ;

HOCKMEYER, WT ;

MALOY, WL ;

HAYNES, JD ;

SCHNEIDER, I ;

ROBERTS, D ;

SANDERS, GS ;

REDDY, EP ;

DIGGS, CL ;

MILLER, LH .

SCIENCE, 1984, 225 (4662) :593-599

[8] Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii [J].

Dobrowolski, JM ;

Carruthers, VB ;

Sibley, LD .

MOLECULAR MICROBIOLOGY, 1997, 26 (01) :163-173

[9] Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite [J].

Dobrowolski, JM ;

Sibley, LD .

CELL, 1996, 84 (06) :933-939

[10] CIRCUMSPOROZOITE GENE OF PLASMOIDIUM-CYNOMOLGI (GOMBAK) - CDNA CLONING AND EXPRESSION OF THE REPETITIVE CIRCUMSPOROZOITE EPITOPE [J].

ENEA, V ;

ARNOT, D ;

SCHMIDT, EC ;

COCHRANE, A ;

GWADZ, R ;

NUSSENZWEIG, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7520-7524

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