Borax as an efficient metal-free catalyst for hetero-Michael reactions in an aqueous medium

被引：59

作者：

Hussain, Sahid ^{[1
]}

Bharadwaj, Saitanya K. ^{[1
]}

Chaudhuri, Mihir K. ^{[1
]}

Kalita, Harjyoti ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 02期

关键词：

borax; thiols amines; water; Michael addition;

D O I：

10.1002/ejoc.200600691

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Borax, a naturally occurring material, very efficiently catalyzed the conjugate addition of thiols, dithiols and amines to alpha,beta-unsaturated ketones, nitriles, amides, aldehydes and esters in an aqueous medium to afford the corresponding Michael adducts in good yields at room temperature. Recycling of the catalyst and scaling up of the reactions are important attributes of this catalysis. The reactions of thiols and dithiols were relatively more facile than those of the corresponding amines. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

引用

页码：374 / 378

页数：5

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