The cunning little vixen: Foxo and the cycle of life and death

被引：132

作者：

Hedrick, Stephen M. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Mol Biol Sect, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 10期

关键词：

FORKHEAD TRANSCRIPTION FACTOR; PROTEIN-KINASE-B; NF-KAPPA-B; OXIDATIVE-STRESS; T-CELLS; TGF-BETA; PHOSPHATIDYLINOSITOL; 3-KINASE; FACTOR AFX; PROMOTES TUMORIGENESIS; IMMUNOLOGICAL SYNAPSE;

D O I：

10.1038/ni.1784

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A screen for increased longevity in Caenorhabditis elegans has identified a transcription factor that programs cells for resistance to oxidative stress, DNA repair and cell cycle control. The mammalian orthologs of this factor are referred to as 'Foxo' for 'Forkhead box', with the second 'o' in the name denoting a subfamily of four members related by sequence. This family of factors is regulated by growth factors, oxidative stress or nutrient deprivation. Thus, it might readily control the inflammatory conflagration associated with infection-driven lymphocyte proliferation. Surprisingly, the first insights into Foxo-mediated immune regulation have instead revealed direct control of highly specialized genes of the adaptive immune system.

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页码：1057 / 1063

页数：7

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