Liver injury in α1-antitrypsin deficiency:: an aggregated protein induces mitochondrial injury

被引：135

作者：

Perlmutter, DH ^{[1
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2002年 / 110卷 / 11期

关键词：

D O I：

10.1172/JCI200216787

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：1579 / 1583

页数：5

共 50 条

[1] Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact [J].

Achleitner, G ;

Gaigg, B ;

Krasser, A ;

Kainersdorfer, E ;

Kohlwein, SD ;

Perktold, A ;

Zellnig, G ;

Daum, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (02) :545-553

[2] Mitochondria recycle Ca2+ to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions [J].

Arnaudeau, S ;

Kelley, WL ;

Walsh, JV ;

Demaurex, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :29430-29439

[3] Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z:: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT deficiency [J].

Burrows, JAJ ;

Willis, LK ;

Perlmutter, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1796-1801

[4] Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways [J].

Cabral, CM ;

Choudhury, P ;

Liu, Y ;

Sifers, RN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :25015-25022

[5] ACCUMULATION OF PIZ ALPHA-1-ANTITRYPSIN CAUSES LIVER-DAMAGE IN TRANSGENIC MICE [J].

CARLSON, JA ;

ROGERS, BB ;

SIFERS, RN ;

FINEGOLD, MJ ;

CLIFT, SM ;

DEMAYO, FJ ;

BULLOCK, DW ;

WOO, SLC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1183-1190

[6] Conformational disease [J].

Carrell, RW ;

Lomas, DA .

LANCET, 1997, 350 (9071) :134-138

[7] ALPHA-1-ANTITRYPSIN DEFICIENCY, EMPHYSEMA, AND LIVER-DISEASE - GENETIC-BASIS AND STRATEGIES FOR THERAPY [J].

CRYSTAL, RG .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1343-1352

[8] Association of calnexin with mutant peripheral myelin protein-22 ex vivo:: A basis for "gain-of-function" ER diseases [J].

Dickson, KM ;

Bergeron, JJM ;

Shames, I ;

Colby, J ;

Nguyen, DT ;

Chevet, E ;

Thomas, DY ;

Snipes, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9852-9857

[9] NEONATAL HEPATITIS INDUCED BY ALPHA-1-ANTITRYPSIN - A TRANSGENIC MOUSE MODEL [J].

DYCAICO, MJ ;

GRANT, SGN ;

FELTS, K ;

NICHOLS, WS ;

GELLER, SA ;

HAGER, JH ;

POLLARD, AJ ;

KOHLER, SW ;

SHORT, HP ;

JIRIK, FR ;

HANAHAN, D ;

SORGE, JA .

SCIENCE, 1988, 242 (4884) :1409-1412

[10] The mitochondrial permeability transition initiates autophagy in rat hepatocytes [J].

Elmore, SP ;

Qian, T ;

Grissom, SF ;

Lemasters, JJ .

FASEB JOURNAL, 2001, 15 (10) :2286-+

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