Copper-mediated reaction of 2-halopyridines with ethyl bromodifluoroacetate

被引：36

作者：

Ashwood, MS

Cottrell, IF

Cowden, CJ

Wallace, DJ

Davies, AJ

Kennedy, DJ

Dolling, UH

机构：

[1] Merck Sharp & Dohme Res Labs, Dept Proc Res, Hoddesdon EN11 9BU, Herts, England

[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(02)02276-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile process for the preparation of substituted ethyl 2'-pyridyldifluoroacetates 3 is described starting from readily available ethyl bromodifluoroacetate 2 and substituted 2-bromo or 2-chloropyridines 1. This process features a copper-mediated cross-coupling reaction in DMSO and is the first to utilise pyridylbromides or chlorides with ethyl bromodifluoroacetate 2 in this reaction. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：9271 / 9273

页数：3

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