Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient

被引：81

作者：

Chapeland-Leclerc, Florence ^{[2
]}

Hennequin, Christophe ^{[3
]}

Papon, Nicolas ^{[4
]}

Noel, Thierry ^{[5
]}

Girard, Aurelie ^{[3
]}

Socie, Gerard

Ribaud, Patricia

Lacroix, Claire ^{[1
,6
]}

机构：

[1] Hop St Louis, Lab Parasitol Mycol, F-75475 Paris 10, France

[2] Univ Paris 05, EA Eucaryotes Pathogenes Transports Membranaires, Paris, France

[3] Hop St Antoine, Lab Parasitol Mycol, APHP, F-75571 Paris, France

[4] Univ Tours, Fac Pharmaceut Sci, EA Biomol & Biotechnol Vegetales 2106, Tours, France

[5] Univ Bordeaux 2, CNRS, UMR 5234, Lab Microbiol Cellulaire & Mol & Pathogen, F-33076 Bordeaux, France

[6] Lab Mycol Parasitol, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 03期

关键词：

GLOBAL ANTIFUNGAL SURVEILLANCE; INVASIVE CANDIDIASIS; CROSS-RESISTANCE; SUSCEPTIBILITY; FLUCONAZOLE; VORICONAZOLE; BREAKPOINTS; LUSITANIAE; MECHANISMS; SECONDARY;

D O I：

10.1128/AAC.01138-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.

引用

页码：1360 / 1362

页数：3

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